Abstract The presence of ecgonine in urine has been proposed as an appropriate marker of cocaine use. Only a few methods have been published for their determination along with cocaine and the rest

A rapid, rugged, and highly specific assay for the quantitation of cocaine (COC) and especially its primary metabolites benzoylecgonine (BZE) and ecgonine methyl ester (EME) in human urine has

Ecgonine. Methylester. Nifedipin. Tetrahydrokortison Urine Testing for drugs of Abuse.

Ecgonine methyl ester in urine

After extraction and sample cleanup by solid-phase extraction (SPE), the extracts were derivatized with 50 μL of MTBSTFA and analyzed by gas chromatography/mass spectrometry (GC/MS). The limit of detection (LOD) was 50 ng/mL for both metabolites. Ambre JJ, Ruo TI, Smith GL, Backes D, Smith CM 1982 Ecgonine methyl ester, a major metabolite of cocaine. J Anal Toxicol 6 : 26–29. CAS Article Google Scholar A rapid, sensitive, reliable quantitative GC/MS method using 0.2 mL of urine was developed for the confirmation of cocaine use.

Other metabolites such as norcocaine and cocaethylene have been analyzed in both blood and urine, but most laboratories use methods that detect cocaine, BE and EME. The excretion kinetics of cocaine (C) and its two major metabolites, benzoylecgonine (BZ) and ecgonine methyl ester (EME), were determined by collecting all urine for 30 h from 5 cocaine users (subjects C, D, E, F, and G) given bolus doses followed by exponential cocaine infusions that delivered doses of 253 (subject C), 444 (subjects D, E, and F), and 700 mg (subject G). The two major urinary metabolites of cocaine are benzoylecgonine (BE) and ecgonine methyl ester (EME). The major advantage of BE screening is that many commercial immunoassays are designed to detect BE. On the other hand, EME is more amenable to gas chromatographic screening. Version 2.69 80144-9Ecgonine methyl ester [Presence] in Urine by Screen methodActive Part Description LP28530-1 Ecgonine methyl ester Ecgonine methyl ester (EME) is a major metabolite of cocaine, a wide spread illicit drug of abuse.

In this study, 25 postmortem urine specimens testing positive, for cocaine and ecogonine methyl ester (EME) by full scan electron impact gas chromatography/mass spectrometry, were used to evaluate the stability of EME in refrigerated and frozen conditions. After an initial quantitation (t = 0), these specimens were split and stored at either 4 degrees C or -20 degrees C.

Tetrahydrokortison Urine Testing for drugs of Abuse. National.

The Origin and Significance of Ecgonine Methyl Ester in Blood Samples. Journal of Analytical Toxicology, 1994. Barry Logan

Ecgonine methyl ester: Description: Ecgonine methyl ester, also known as methyl ecgonine, belongs to the class of organic compounds known as tropane alkaloids. These are organic compounds containing the nitrogenous bicyclic alkaloid parent N-Methyl-8-azabicyclo[3.2.1]octane. Ecgonine methyl ester is a major metabolite of cocaine. DOI: 10.1093/jat/15.6.345 Corpus ID: 6628777. Sensitive, selective, and rapid procedure for the identification of ecgonine methyl ester in urine. @article{Vasiliades1989SensitiveSA, title={Sensitive, selective, and rapid procedure for the identification of ecgonine methyl ester in urine.}, author={J. Vasiliades}, journal={Journal of analytical toxicology}, year={1989}, volume={13 2}, pages Esters Toxicology screen, general (procedure) Urine ecgonine methyl ester.

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Cocaine, benzoylecgonine, and ecgonine methyl ester determinations in postmortem urine and blood gas chromatography and capillary gas chromatography after Extrelut extraction Italiano English Chemsrc provides ecgonine methyl ester(CAS#:7143-09-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of ecgonine methyl ester are included as well.
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This work describes a fast and fully validated procedure for the simultaneous detection and quantification of ecgonine, ecgonine‐methyl‐ester, benzoylecgonine, nor‐benzoylecgonine, m‐hydroxybenzoylecgonine, cocaethylene, cocaine, norcocaine and norcocaethylene in human urine (500 μL) using one SPE and simple derivatization.

A rapid, rugged, and highly specific assay for the quantitation of cocaine (COC) and especially its primary metabolites benzoylecgonine (BZE) and ecgonine methyl ester (EME) in human urine … Urine or plasma or serum is spiked with deuterated internal standards cocaine-d3, benzoylecgonine-d3, ecgonine methyl ester-d3, and cocaethylene-d3 and buffered with phosphate buffer. The drugs in the sample are extracted by cation-exchange solid phase extraction. In this study, 25 postmortem urine specimens testing positive, for cocaine and ecogonine methyl ester (EME) by full scan electron impact gas chromatography/mass spectrometry, were used to evaluate the stability of EME in refrigerated and frozen conditions. After an initial quantitation (t = 0), these specimens were split and stored at either 4 degrees C or -20 degrees C. Cocaine, Benzoylecgonine and Ecgonine Methyl Ester Determinations in Post Mortem Human Urine and Blood by Gas Chromatography and Capillary Gas Chromatography after “Extrelut®” Extraction | SpringerLink. Developments in Analytical Methods in Pharmaceutical, Biomedical, and Forensic Sciences. Sensitive, selective, and rapid procedure for the identification of ecgonine methyl ester in urine. Vasiliades J. PMID: 2733392 [PubMed - indexed for MEDLINE] Publication Types: Letter; MeSH Terms.